Features & Interviews
Candid, in-depth dialogues with the principal investigators, foundry architects, and physician-scientists rewriting biology from the atomic scale up.
“We Are Transitioning From Evolving Proteins by Chance to Compiling Them Like Software”
“Biology used to be an observational discipline. Today, it is an architectural engineering substrate.”
Prof. Baker discusses how zero-shot generative models and RFdiffusion are cutting candidate screening times from 18 months down to 4 days, and why de novo protein architecture will revolutionize therapeutics.
Prof. David Baker
2024 Nobel Laureate & Director of Institute for Protein Design
University of Washington & HHMI
Archive of Scientific Inquiries
3 ConversationsProf. David Baker
2024 Nobel Laureate & Director of Institute for Protein Design
University of Washington & HHMI
“We Are Transitioning From Evolving Proteins by Chance to Compiling Them Like Software”
Prof. Baker discusses how zero-shot generative models and RFdiffusion are cutting candidate screening times from 18 months down to 4 days, and why de novo protein architecture will revolutionize therapeutics.
Prof. Shinya Yamanaka
2012 Nobel Laureate in Physiology or Medicine
Kyoto University & Gladstone Institutes
“Aging Is Not a Thermodynamic Inevitability; It Is an Epigenetic Information Loss Problem”
In this retrospective dialogue, Prof. Yamanaka analyzes twenty years of Yamanaka factor research, why transient pulsatile reprogramming bypasses teratomas, and the hurdles in measuring true human biological age in non-human primates.
Prof. Frances Arnold
2018 Nobel Laureate in Chemistry
California Institute of Technology (Caltech)
“Directed Evolution: Teaching Enzymes to Do What Nature Never Needed Them to Do”
Prof. Arnold recounts how introducing evolutionary pressure in test tubes created catalysts for carbon-silicon bonds, sustainable aviation fuels, and plastics deconstruction without toxic reagents.