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4 Active Debates
Longevity14m ago

Partial Reprogramming: Will OSK pulses ever translate to solid organs without teratoma risk?

The recent Basel data on endothelial rejuvenation is remarkable, but hepatic and renal delivery presents a vastly different epigenetic threshold. What safety kill-switches are currently being engineered?

Started by Dr. Julian Wu, Karolinska Institute28 Replies
Ecology1h ago

Ecological biosafety: Releasing engineered Symbiodiniaceae into wild Great Barrier Reef colonies

While thermal tolerance at 34°C is established in vitro, horizontal gene transfer between synthetic and wild dinoflagellate lineages in open ocean conditions must be empirically bounded.

Started by Prof. Sarah Lindqvist, James Cook University19 Replies
Microbiome3h ago

Microbiome Therapeutics: Colonization durability vs. continuous daily synthetic dosing

Is the future of living medicines persistent symbiotic engraftment, or fail-safe auxotrophic strains that clear after 72 hours? We examine the regulatory landscape.

Started by Ed Yong, Contributing Science Author34 Replies
AI & Discovery6h ago

Can AI Foundation Models Predict Allosteric Kinase Inhibitor Resistance Before In-Vitro Assays?

Benchmarking AlphaProteome against real-world secondary mutation escape profiles in non-small cell lung cancer EGFR tyrosine kinase inhibitors.

Started by Kavita Rao, Computational Biochemist15 Replies
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